Skullgirls 2nd Encore is an enhanced version of Skullgirls Encore which was released exclusively for PlayStation 4 and PlayStation Vita on July 7, 2015.
Voices
- Filia: Christine Marie Cabanos
- Samson: Patrick Seitz
- Cerebella: Cristina Vee
- Peacock: Sarah Williams
- Parasoul: Erin Fitzgerald
- Ms. Fortune: Kimlinh Tran
- Painwheel: Danielle McRae
- Valentine: Laura Post
- Double: Charlotte Ann
- Marie: Kira Buckland
- Squigly: Lauren Landa
- Leviathan: Liam O'Brien
- Big Band: Richard Wayne Brown
- Fukua: Christine Marie Cabanos
- Eliza: Michelle Ruff
- Sekhmet: Wendee Lee
- Albus: Christopher Corey Smith
- Horace: Sean Schemmel
- Beowulf: Kai Kennedy
- Robo-Fortune: Kimlinh Tran
- Skull Heart: Cassandra Lee & Cristina Vee
- Mrs Victoria: Wendee Lee
- Announcer: Joshua Tomar
- Annie: Erica Mendez
- Zane: Matthew Mercer
- Minette: Cassandra Lee
- Umbrella: Cassandra Lee
- Black Dahlia: Wendee Lee
- Brain Drain: Kaiji Tang
- Venus: Lauren Landa
- Aeon: Cristina Vee
- Yu-Wan: Kaiji Tang
- Molly: Cassandra Lee
- Adam: Christopher Smith
- Ileum: Laura Post
- Stanley: Christopher Smith
- Avery: Christine Marie Cabanos
- Tommy: Mike Zaimont
- Andy: Kaiji Tang
- Hive: Erin Fitzgerald
- Feng: Kira Buckland
- Dr. Avian: Liam O'Brien
- Leduc: Kyle Hebert
- Riccardo: Kyle Hebert
- Vitale: Kyle Hebert
- Lorenzo: Mike Zaimont
- Reporter: Cristina Vee
- Soldier: Kaiji Tang
- Soldier: Bobby Thong
- Soldier: Erik Kimerer
- Soldier: Jason Wishnov
- Lawrence: Kaiji Tang
- Irvin: Kyle Hebert
- Dad: Kyle Hebert
- Mother: Charlotte Ann
- Stranger: Charlotte Ann
- Selene: Erin Fitzgerald
- Roberto Contiello: Kyle Hebert
- TV Announcer: Josh Tomar
- Sister Agatha: Charlotte Ann
- Penguin Referee: Christopher Corey Smith
- Grendel: Kaiji Tang